Lypla2 Gene Summary [Mouse]
Enables palmitoyl-(protein) hydrolase activity. Involved in prostaglandin catabolic process and protein depalmitoylation. Located in Golgi stack. Is expressed in several structures, including alimentary system; eye; integumental system; nervous system; and urinary system. Orthologous to human LYPLA2 (lysophospholipase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lypla2 |
| Official Name | lysophospholipase 2 [Source:MGI Symbol;Acc:MGI:1347000] |
| Ensembl ID | ENSMUSG00000028670 |
| Bio databases IDs | |
| Aliases | lysophospholipase 2 |
| Synonyms | APT-2, DJ886K2.4, Lpla2, LysoII, lysophospholipase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lypla2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Serine hydrolase (FSH1)
- lysophospholipase
- alpha/beta hydrolases
- Phospholipase/Carboxylesterase
- enzyme
- protein binding
- palmitoyl-(protein) hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- phospholipidosis
- chronic lymphocytic leukemia
- organismal death
- prostate cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- splenomegaly
regulated by
- Ca2+
- bromoenol lactone
- FIRRE
- mir-322 (includes others)
- calmodulin
- reactive oxygen species
role in cell
- release
- production in
- apoptosis
- oligomerization in
- palmitoylation in
- guidance
- depalmitoylation in
- bacterial burden
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- Plasma Membrane
- cytosol
- Golgi stacks
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lypla2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acylglycerol catabolic process
- protein depalmitoylation
- axon guidance
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- Golgi stack
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- protein binding
- palmitoyl-(protein) hydrolase activity
- cadherin binding
- carboxylic ester hydrolase activity