Ndn Gene Summary [Mouse]
Enables gamma-tubulin binding activity and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including nervous system development; neurotrophin TRK receptor signaling pathway; and regulation of DNA-templated transcription. Located in several cellular components, including centrosome; cytosol; and nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Used to study Prader-Willi syndrome. Human ortholog(s) of this gene implicated in Prader-Willi syndrome. Orthologous to human NDN (necdin, MAGE family member). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndn |
| Official Name | necdin, MAGE family member [Source:MGI Symbol;Acc:MGI:97290] |
| Ensembl ID | ENSMUSG00000033585 |
| Bio databases IDs | |
| Aliases | necdin, MAGE family member |
| Synonyms | AC270095.2, HsT16328, NECDIN, necdin, MAGE family member, Peg6, PWCR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- gamma-tubulin binding
- transcription regulator
- MAGE homology domain
- necdin homology domain
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- lung squamous cell carcinoma
- schizophrenia
- lung adenocarcinoma
- lung adenocarcinoma formation
- colorectal adenoma
- colorectal adenoma formation
- endometrial cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
role in cell
- migration
- proliferation
- apoptosis
- growth
- colony formation
- formation
- differentiation
- activation
- outgrowth
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microsomal fraction
- nuclear fraction
- mitochondrial fraction
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- growth cone
- cellular protrusions
- membrane processes
- perikaryon
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein deacetylation
- post-embryonic development
- positive regulation of transcription from RNA polymerase II promoter
- glial cell migration
- axonal fasciculation
- negative regulation of transcription from RNA polymerase II promoter
- respiratory system process
- nerve growth factor receptor signaling pathway
- neuron migration
- central nervous system development
- axon extension
- multicellular organismal homeostasis
- sensory perception of pain
- genetic imprinting
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytosol
- macromolecular complex
- perikaryon
- cell projection
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- gamma-tubulin binding