Sema3e Gene Summary [Mouse]
Enables semaphorin receptor binding activity. Involved in several processes, including angiogenesis; negative regulation of angiogenesis; and negative regulation of cell-matrix adhesion. Located in extracellular space. Is expressed in several structures, including cochlea; embryo mesenchyme; hemolymphoid system gland; nervous system; and nose. Orthologous to human SEMA3E (semaphorin 3E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Sema3e |
| Official Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E [Source:MGI Symbol;Acc:MGI:1340034] |
| Ensembl ID | ENSMUSG00000063531 |
| Bio databases IDs | |
| Aliases | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E |
| Synonyms | 6430702L12, coll-5, LOC108350656, mKIAA0331, M-SEMAH, M-SemaK, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E, SEMAH, SEMAPHORIN 3E |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema3e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- Plexin repeat
- semaphorin receptor binding
- immunoglobulin domain
- receptor agonist activity
- protein binding
- Sema domain
- Immunoglobulin V-set domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema3e gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- proliferative diabetic retinopathy
- myopia
- nephrosis
- femoral fracture
- hypogonadotropic hypogonadism 5
- airway hyperresponsiveness
- retinitis pigmentosa
- vascular dementia
- CHARGE syndrome
role in cell
- expression in
- activation in
- apoptosis
- binding in
- phosphorylation in
- number
- formation
- chemorepulsion
- organization
- collapse
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema3e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- negative regulation of angiogenesis
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus
- negative chemotaxis
- synapse organization
- sprouting angiogenesis
- axon guidance
- negative regulation of neuron apoptotic process
- negative regulation of cell-matrix adhesion
- neural crest cell migration
- patterning of blood vessels
- positive regulation of protein kinase B signaling cascade
- semaphorin-plexin signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor agonist activity
- chemorepellent activity
- semaphorin receptor binding