Arrb1 Gene Summary [Mouse]
Enables cysteine-type endopeptidase inhibitor activity and mitogen-activated protein kinase kinase binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of cell communication; and ubiquitin-dependent protein catabolic process. Acts upstream of or within phototransduction and regulation of G protein-coupled receptor signaling pathway. Located in cytosol and pseudopodium. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and respiratory system. Orthologous to human ARRB1 (arrestin beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arrb1 |
| Official Name | arrestin, beta 1 [Source:MGI Symbol;Acc:MGI:99473] |
| Ensembl ID | ENSMUSG00000018909 |
| Bio databases IDs | |
| Aliases | arrestin, beta 1 |
| Synonyms | 1200006I17RIK, ARB1, ARR1, Arr2, Arrestin-2, arrestin beta 1, arrestin, beta 1, Arrestin β 1, arrestin, β 1, BARRES, Beta1 Arrestin, beta ARR1, beta ARRESTIN 1, G430100A01Rik, Hs.568928, β ARR1, β ARRESTIN 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arrb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Src binding domain
- transcription regulator
- transcription co-activator
- protein kinase binding
- protein binding activity, bridging
- enzyme inhibitor activity
- G-protein-coupled receptor binding
- phosphoprotein binding
- enzyme binding
- clathrin binding
- GTPase activator
- estrogen receptor binding
- Arrestin (or S-antigen), N-terminal domain
- protein binding
- receptor binding
- insulin-like growth factor receptor binding
- phosphoprotein amino acid binding
- phosphorylation site
- Arrestin (or S-antigen), C-terminal domain
- cysteine protease inhibitor activity
- binding protein
- ion channel binding
Pathways
Biological processes and signaling networks where the Arrb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- collagen-induced arthritis
- small cell lung cancer
- mechanical hyperalgesia
- rheumatoid arthritis
- experimental autoimmune encephalomyelitis
- obstructive sleep apnea
- obesity
- cognitive impairment
- infiltrating ductal breast carcinoma
regulated by
- Francisella tularensis subsp. holarctica LVS
- dexamethasone
- insulin
- ERK1/2
- beta-estradiol
- dopamine
- epinephrine
- NR3C1
- okadaic acid
- carbon tetrachloride
role in cell
- apoptosis
- binding in
- expression in
- chemotaxis
- phosphorylation in
- formation
- formation in
- function
- migration
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endocytic vesicle membrane
- cytoplasmic vesicle membrane
- cell surface
- intracellular space
- Nucleus
- Plasma Membrane
- endosomes
- centrosome
- cytosol
- postsynaptic membrane
- basolateral membrane
- Golgi membrane
- lysosome membrane
- nucleoplasm
- nuclear bodies
- dendritic spines
- cytoplasmic vesicles
- pseudopodia
- chromatin
- postsynaptic density
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arrb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- signal transduction
- positive regulation of receptor internalization
- negative regulation of NF-kappaB transcription factor activity
- protein transport
- G-protein coupled receptor internalization
- visual perception
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of Notch signaling pathway
- stress fiber assembly
- regulation of transcription from RNA polymerase II promoter
- ubiquitin-dependent protein catabolic process
- negative regulation of interleukin-6 production
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of interleukin-8 production
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of protein ubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nuclear body
- Golgi membrane
- chromatin
- lysosomal membrane
- plasma membrane
- nucleoplasm
- nucleus
- cytoplasmic vesicle membrane
- cytoplasm
- coated pit
- cytosol
- cytoplasmic vesicle
- pseudopodium
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- histone acetyltransferase activity
- angiotensin receptor binding
- protein binding
- ubiquitin protein ligase binding
- transcription coactivator activity
- enzyme inhibitor activity
- GTPase activator activity
- insulin-like growth factor receptor binding