Ak2 Gene Summary [Rat]
Enables adenylate kinase activity. Contributes to nucleobase-containing compound kinase activity. Involved in several processes, including liver development; purine nucleotide metabolic process; and response to thyroid hormone. Predicted to be located in sperm mitochondrial sheath. Predicted to be active in mitochondrion. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ak2 |
| Official Name | adenylate kinase 2 [Source:RGD Symbol;Acc:2077] |
| Ensembl ID | ENSRNOG00000000122 |
| Bio databases IDs | |
| Aliases | adenylate kinase 2 |
| Synonyms | adenylate kinase 2, ADK2, D4Ertd220e |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ak2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- nucleobase, nucleoside, nucleotide kinase
- adenylate kinase
- NK
- adenylate kinase, isozyme 1 subfamily
- UMP-CMP kinase family
- protein binding
- AAA domain
- Adenylate kinase, active site lid
Pathways
Biological processes and signaling networks where the Ak2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- glioblastoma cancer
- glioma formation
- reticular dysgenesis
- hepatocellular carcinoma
- liver cancer
- severe combined immunodeficiency
- low-grade glioma
- nicotine dependence
- glioblastoma
role in cell
- proliferation
- growth
- phosphorylation in
- migration
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- mitochondrial intermembrane space
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ak2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ADP biosynthetic process
- AMP metabolic process
- ATP metabolic process
- nucleobase-containing small molecule interconversion
- nucleoside monophosphate phosphorylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- extracellular vesicular exosome
- cytoplasm
- sperm mitochondrial sheath
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- ATP binding
- adenylate kinase activity
- protein binding