Ncoa5 Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within glucose homeostasis and negative regulation of insulin receptor signaling pathway. Predicted to be located in actin cytoskeleton. Predicted to be active in nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human NCOA5 (nuclear receptor coactivator 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncoa5 |
| Official Name | nuclear receptor coactivator 5 [Source:MGI Symbol;Acc:MGI:2385165] |
| Ensembl ID | ENSMUSG00000039804 |
| Bio databases IDs | |
| Aliases | nuclear receptor coactivator 5 |
| Synonyms | bA465L10.6, CIA, KIAA1637, MGC28864, nuclear receptor coactivator 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncoa5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LXXLL motif
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anxiety disorder
- epithelial cancer
- abdominal cancer
- epithelial neoplasia
- cancer
- fibrosis
- liver cancer
- liver neoplasia
- digestive system cancer
- neuroticism
regulated by
- beta-estradiol
- raloxifene
- tamoxifen
- Collagen(s)
- tretinoin
- acolbifene
- fulvestrant
- RARA
- estrogen
- VPC-220010
role in cell
- apoptosis
- quantity
- expression in
- proliferation
- number
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- actin cytoskeleton
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncoa5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- insulin receptor signaling pathway
- glucose homeostasis
- regulation of signal transduction
- negative regulation of insulin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- actin cytoskeleton
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- transcription corepressor activity
- chromatin binding