Ctnnbip1 Gene Summary [Mouse]
Enables beta-catenin binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of smooth muscle cell proliferation; and regulation of DNA-templated transcription. Acts upstream of or within anterior/posterior pattern specification; branching involved in ureteric bud morphogenesis; and negative regulation of Wnt signaling pathway. Part of beta-catenin-ICAT complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human CTNNBIP1 (catenin beta interacting protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctnnbip1 |
| Official Name | catenin beta interacting protein 1 [Source:MGI Symbol;Acc:MGI:1915756] |
| Ensembl ID | ENSMUSG00000028988 |
| Bio databases IDs | |
| Aliases | catenin beta interacting protein 1 |
| Synonyms | 1110008O09Rik, 2310001I19Rik, catenin beta interacting protein 1, catenin, beta-interacting protein 1, catenin β interacting protein 1, catenin, β-interacting protein 1, CATNBIP1, ICAT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctnnbip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-catenin binding
- Beta-catenin-interacting protein ICAT
- helical domain
- transcription factor binding
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- anophthalmia
- exencephaly
- idiopathic scoliosis
- venous thromboembolism
- plaque psoriasis
- developmental delay
role in cell
- expression in
- apoptosis
- growth
- morphology
- differentiation
- proliferation
- invasion by
- inhibition in
- binding in
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctnnbip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterior/posterior pattern specification
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of osteoblast differentiation
- negative regulation of protein binding
- negative regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of monocyte differentiation
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of mesenchymal cell proliferation
- branching involved in ureteric bud morphogenesis
- negative regulation of smooth muscle cell proliferation
- regulation of vascular permeability involved in acute inflammatory response
- Wnt receptor signaling pathway
- negative regulation of protein complex assembly
- negative regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- beta-catenin destruction complex
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- armadillo repeat domain binding
- beta-catenin binding