Iqgap2 Gene Summary [Mouse]
Predicted to enable several functions, including Arp2/3 complex binding activity; GTPase activator activity; and calmodulin binding activity. Predicted to be involved in actin filament organization; regulation of actin cytoskeleton organization; and thrombin-activated receptor signaling pathway. Located in microvillus. Is expressed in several structures, including alimentary system; axial skeleton; central nervous system; genitourinary system; and liver. Used to study hepatocellular carcinoma. Orthologous to human IQGAP2 (IQ motif containing GTPase activating protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Iqgap2 |
| Official Name | IQ motif containing GTPase activating protein 2 [Source:MGI Symbol;Acc:MGI:2449975] |
| Ensembl ID | ENSMUSG00000021676 |
| Bio databases IDs | |
| Aliases | IQ motif containing GTPase activating protein 2 |
| Synonyms | 4933417J23RIK, A630053O10, AI788777, IQ motif containing GTPase activating protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Iqgap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase binding domain
- Calponin homology domain
- calmodulin binding
- RasGAP C-terminus
- enzyme binding
- Ras GTPase Activating Domain
- actin filament binding
- GTPase-activator protein for Ras-like GTPases
- Calmodulin-binding motif
- Domain with 2 conserved Trp (W) residues
- binding protein
- GTPase inhibitor
- phosphatidylinositol-3,4,5-triphosphate binding
- actin binding
- IQ domain
- WW
- GTPase-activator protein for Ras-like GTPase
- calponin homology (CH) domain superfamily
Pathways
Biological processes and signaling networks where the Iqgap2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- neoplasia
- benign neoplasia
- progression free survival
role in cell
- cell death
- apoptosis
- phosphorylation in
- proliferation
- number
- formation
- formation in
- organization
- cross-linkage
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- actin cytoskeleton
- Plasma Membrane
- microtubules
- secretory granule membrane
- cytosol
- cortical actin filaments
- microvilli
- filopodia
- filopodial tip
- podocyte slit diaphragm
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Iqgap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- thrombin receptor signaling pathway
- regulation of actin cytoskeleton organization
- signal transduction
- Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular vesicular exosome
- cytoplasm
- microvillus
- cell cortex
- actin cytoskeleton
- filopodium
- cytosol
- plasma membrane
- cell surface
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- actin filament binding
- calmodulin binding
- GTPase inhibitor activity
- actin binding
- GTPase activator activity
- small GTPase binding
- Arp2/3 complex binding