Htra3 Gene Summary [Mouse]
Enables serine-type peptidase activity. Involved in negative regulation of BMP signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; and proteolysis. Predicted to be located in extracellular region. Is expressed in decidua; forelimb; and tendon. Orthologous to human HTRA3 (HtrA serine peptidase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htra3 |
| Official Name | HtrA serine peptidase 3 [Source:MGI Symbol;Acc:MGI:1925808] |
| Ensembl ID | ENSMUSG00000029096 |
| Bio databases IDs | |
| Aliases | HtrA serine peptidase 3 |
| Synonyms | 2210021K23RIK, 9530081K03RIK, HtrA serine peptidase 3, Prsp, RGD1308120, Tasp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Htra3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tryp_SPc
- peptidase
- canonical PDZ domain
- protein binding
- PDZ domain
- identical protein binding
- endopeptidase
- trypsin
- serine-type peptidase
- Trypsin-like peptidase domain
- Insulin-like growth factor binding protein
- cpPDZ_Deg_HtrA-like
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Htra3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- multiple system atrophy
- organismal death
- ulcerative colitis
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
regulated by
- decitabine
- USP37
- etoposide
- tributyltin
- cAMP analogs
- beta-estradiol
- medroxyprogesterone acetate
- diethylstilbestrol
- AGN194204
- epicatechin
role in cell
- cell death
- apoptosis
- survival
- proliferation
- cell survival
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Htra3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- proteolysis
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- serine-type endopeptidase activity
- serine-type peptidase activity
- endopeptidase activity