Htra4 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Predicted to be involved in positive regulation of apoptotic process; programmed cell death; and proteolysis. Predicted to be located in extracellular region. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; lung; and muscle tissue. Orthologous to human HTRA4 (HtrA serine peptidase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htra4 |
| Official Name | HtrA serine peptidase 4 [Source:MGI Symbol;Acc:MGI:3036260] |
| Ensembl ID | ENSMUSG00000037406 |
| Bio databases IDs | |
| Aliases | HtrA serine peptidase 4 |
| Synonyms | B430206E18Rik, HtrA serine peptidase 4, RGD1306242 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Htra4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tryp_SPc
- peptidase
- canonical PDZ domain
- protein binding
- PDZ domain
- KAZAL_FS
- identical protein binding
- endopeptidase
- trypsin
- Trypsin-like peptidase domain
- Insulin-like growth factor binding protein
- cpPDZ_Deg_HtrA-like
- cpPDZ_RseP_YlbL-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multicentric carpotarsal osteolysis syndrome
- habitual abortion
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- proliferation
- expression in
- phosphorylation in
- migration
- fusion
- invasion by
- cell cycle progression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Htra4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- positive regulation of apoptotic process
- programmed cell death
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- serine-type endopeptidase activity
- endopeptidase activity