Plb1 Gene Summary [Mouse]
Predicted to enable carboxylic ester hydrolase activity. Acts upstream of or within positive regulation of acrosome reaction. Predicted to be located in apical plasma membrane. Predicted to be active in brush border membrane. Is expressed in diencephalon lateral wall mantle layer; hypothalamus mantle layer; lung; midbrain mantle layer; and telencephalon mantle layer. Orthologous to human PLB1 (phospholipase B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Plb1 |
| Official Name | phospholipase B1 [Source:MGI Symbol;Acc:MGI:1922406] |
| Ensembl ID | ENSMUSG00000029134 |
| Bio databases IDs | |
| Aliases | phospholipase B1 |
| Synonyms | 4632413E21RIK, 4930433E17Rik, 4930539A06RIK, BC033606, LOC192259, Lplipase, Phlpb, phospholipase B1, PLB, PLB/LIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SGNH_hydrolase
- GDSL-like Lipase/Acylhydrolase family
- lysophospholipase
- catalytic domain
- calcium-independent phospholipase A2
- enzyme
- protein binding
- retinyl-palmitate esterase
- GDSL-like Lipase/Acylhydrolase
- phospholipase A2
- triacylglycerol lipase
Pathways
Biological processes and signaling networks where the Plb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- scarlet fever
- cerebral aneurysm
- soft tissue sarcoma cancer
- non-insulin-dependent diabetes mellitus
- hyperhidrosis
- COVID-19
- chronic obstructive pulmonary disease
- cataract
- desmoplastic small round cell tumor
- exostoses
regulates
- phospholipid
- phosphatidylcholine
- triacylglycerol
- phosphatidylethanolamine
- diacylglycerol
- F5cys-MP-PEG(2000)-DPSE
- phosphatidylglycerol
- retinoid
- MIA
- retinol
role in cell
- exocytosis by
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- acrosome plasma membrane
- Plasma Membrane
- acrosome
- cytoplasmic droplets
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- diacylglycerol catabolic process
- phosphatidylcholine catabolic process
- retinoid metabolic process
- phosphatidylcholine acyl-chain remodeling
- retinol metabolic process
- positive regulation of acrosome reaction
- phosphatidylglycerol catabolic process
- triglyceride catabolic process
- phospholipid metabolic process
- phosphatidylethanolamine catabolic process
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- lysophospholipase activity
- calcium-independent phospholipase A2 activity
- retinyl-palmitate esterase activity
- triglyceride lipase activity