Lingo2 Gene Summary [Mouse]
Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in glutamatergic synapse and synaptic membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including central nervous system and nose. Orthologous to human LINGO2 (leucine rich repeat and Ig domain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lingo2 |
| Official Name | leucine rich repeat and Ig domain containing 2 [Source:MGI Symbol;Acc:MGI:2442298] |
| Ensembl ID | ENSMUSG00000045083 |
| Bio databases IDs | |
| Aliases | leucine rich repeat and Ig domain containing 2 |
| Synonyms | B230217C06Rik, FLJ31810, LERN3, leucine rich repeat and Ig domain containing 2, LOC108353483, LOC124906826, LRRN6C, RGD1310773 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lingo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- Leucine rich repeat
- Immunoglobulin I-set domain
- Leucine rich repeat C-terminal domain
- Leucine rich repeat N-terminal domain
- BspA type Leucine rich repeat region (6 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- breast carcinoma
- Alzheimer disease
- metabolic syndrome X
- obesity
- neuroticism
- acute myeloid leukemia
- self-abusive behavior
- diabetes mellitus
role in cell
- expression in
- cell death
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cell surface
- Plasma Membrane
- synaptic membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lingo2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- extracellular matrix