Stap1 Gene Summary [Mouse]
Enables macrophage colony-stimulating factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including negative regulation of macrophage colony-stimulating factor signaling pathway; negative regulation of macrophage migration; and negative regulation of ruffle assembly. Acts upstream of or within response to bacterium. Predicted to be located in several cellular components, including centriolar satellite; mitochondrion; and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human STAP1 (signal transducing adaptor family member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stap1 |
| Official Name | signal transducing adaptor family member 1 [Source:MGI Symbol;Acc:MGI:1926193] |
| Ensembl ID | ENSMUSG00000029254 |
| Bio databases IDs | |
| Aliases | signal transducing adaptor family member 1 |
| Synonyms | BRDG1, RGD1311584, signal transducing adaptor family member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- receptor tyrosine kinase binding
- macrophage colony stimulating factor receptor binding
- protein binding activity, bridging
- Src homology 2 (SH2) domain
- phosphotyrosine binding
- protein binding
- Pleckstrin homology-like domain
- transmembrane receptor protein tyrosine kinase adaptor protein
- protein tyrosine kinase activator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- insulin-dependent diabetes mellitus
- prostate cancer
- familial hyperlipoproteinemia type IIa
- chronic obstructive pulmonary disease
- Parkinson disease
- hepatic necrosis
- uveal melanoma
- ocular melanoma
role in cell
- production in
- phosphorylation in
- expression in
- quantity
- differentiation
- formation
- phagocytosis by
- assembly
- formation in
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- Mitochondria
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of B cell receptor signaling pathway
- positive regulation of phagocytosis, engulfment
- cellular response to lipopolysaccharide
- positive regulation of gene expression
- transmembrane receptor protein tyrosine kinase signaling pathway
- negative regulation of macrophage chemotaxis
- negative regulation of ruffle assembly
- negative regulation of phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- centriolar satellite
- mitochondrion
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein kinase binding
- protein binding
- signaling adaptor activity
- protein tyrosine kinase activator activity
- transmembrane receptor protein tyrosine kinase adaptor activity
- phospholipid binding
- macrophage colony-stimulating factor receptor binding