Hnrnpdl Gene Summary [Mouse]
Predicted to enable DNA binding activity and poly-purine tract binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within mRNA metabolic process. Located in nucleus. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 3. Orthologous to human HNRNPDL (heterogeneous nuclear ribonucleoprotein D like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Hnrnpdl |
| Official Name | heterogeneous nuclear ribonucleoprotein D-like [Source:MGI Symbol;Acc:MGI:1355299] |
| Ensembl ID | ENSMUSG00000029328 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein D-like |
| Synonyms | D5Ertd650e, D5Wsu145e, heterogeneous nuclear ribonucleoprotein D-like, HNRDL, HNRNP, Hnrnpdl1, HNRNP-D LIKE, HNRPDL, JKTBP, JKTBP1, JKTBP2, laAUF1, LGMD1G, LGMDD3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hnrnpdl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- HuR Nucleocytoplasmic Shuttling domain
- single-stranded DNA binding
- double-stranded DNA binding
- RNA recognition motif
- nuclear localization sequence
- poly(A) binding protein
- protein binding
- glycine tyrosine rich domain
- single-stranded RNA binding
- DNA binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- Alzheimer disease
- limb-girdle muscular dystrophy type 1G
- Parkinson disease
- autosomal dominant limb-girdle muscular dystrophy
- Huntington disease
- infection by HIV-1
role in cell
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- synapse
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hnrnpdl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of gene expression
Cellular Component
Where in the cell the gene product is active
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- poly(G) RNA binding
- poly(A) RNA binding