Utp20 Gene Summary [Mouse]
Predicted to be involved in rRNA processing and ribosomal small subunit biogenesis. Predicted to be located in plasma membrane. Predicted to be part of 90S preribosome and small-subunit processome. Predicted to be active in nucleolus. Is expressed in cerebellum; cerebral cortex; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human UTP20 (UTP20 small subunit processome component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Utp20 |
| Official Name | UTP20 small subunit processome component [Source:MGI Symbol;Acc:MGI:1917933] |
| Ensembl ID | ENSMUSG00000004356 |
| Bio databases IDs | |
| Aliases | UTP20 small subunit processome component |
| Synonyms | 1A6/DRIM, 3830408P06Rik, DRIM, mDRIM, mDRIN, RGD1560606, UTP20 small subunit processome component |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Utp20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF6700)
- protein binding
- Down-regulated in metastasis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pre-ribosome
- Cytoplasm
- Plasma Membrane
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Utp20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- negative regulation of cell proliferation
- ribosomal small subunit biogenesis
- endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- cytoplasm
- 90S preribosome
- nucleolus
- plasma membrane
- preribosome, small subunit precursor
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding