Wnt2b Gene Summary [Mouse]
Predicted to enable cytokine activity and frizzled binding activity. Involved in forebrain regionalization. Acts upstream of or within several processes, including canonical Wnt signaling pathway; mesenchymal-epithelial cell signaling; and regulation of morphogenesis of a branching structure. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; reproductive system; sensory organ; and urethra. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human WNT2B (Wnt family member 2B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt2b |
| Official Name | wingless-type MMTV integration site family, member 2B [Source:MGI Symbol;Acc:MGI:1261834] |
| Ensembl ID | ENSMUSG00000027840 |
| Bio databases IDs | |
| Aliases | wingless-type MMTV integration site family, member 2B |
| Synonyms | wingless-type MMTV integration site family, member 2B, WNT13, Wnt2a, Wnt family member 2B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wnt2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- wnt family
- protein binding
- receptor binding
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- hypertension
- primary biliary cirrhosis
- stroke
- squamous cell lung cancer
- diarrhea type 9
- lung adenocarcinoma
- lung adenocarcinoma formation
- cardiovascular disorder
- androgenic alopecia
role in cell
- proliferation
- phosphorylation in
- expression in
- binding in
- formation
- production in
- activation in
- oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wnt2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male gonad development
- neuron differentiation
- lung induction
- chondrocyte differentiation
- cellular response to starvation
- mesenchymal-epithelial cell signaling
- lens development in camera-type eye
- cornea development in camera-type eye
- forebrain regionalization
- positive regulation of branching involved in ureteric bud morphogenesis
- cell fate commitment
- hemopoietic stem cell proliferation
- canonical Wnt receptor signaling pathway
- iris morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- intracellular membrane-bounded organelle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- cytokine activity