Rimbp2 Gene Summary [Mouse]
Enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. A structural constituent of presynaptic active zone. Involved in regulation of calcium-dependent activation of synaptic vesicle fusion and regulation of presynaptic membrane potential. Is active in calyx of Held; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Orthologous to human RIMBP2 (RIMS binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rimbp2 |
| Official Name | RIMS binding protein 2 [Source:MGI Symbol;Acc:MGI:2443235] |
| Ensembl ID | ENSMUSG00000029420 |
| Bio databases IDs | |
| Aliases | RIMS binding protein 2 |
| Synonyms | A930033C01Rik, KIAA0318, LOC102724399, mKIAA0318, PPP1R133, RBP2, RIMS binding protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rimbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- Modifier of rudimentary (Mod(r)) protein
- Ezrin/radixin/moesin, alpha-helical domain
- FN3
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- protein binding
- Fibronectin type 3 domain
- structural molecule
- voltage-gated ion channel
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- psychosis
- acute myeloid leukemia
- refractive error
- phobic anxiety disorder
- Parkinson disease
- tension headaches
regulated by
- IL1B
- bucladesine
- calmodulin
regulates
role in cell
- paired-pulse facilitation
- paired-pulse facilitation in
- clustering in
- transmission
- plasticity
- release
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- synaptic membrane
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rimbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuromuscular synaptic transmission
Cellular Component
Where in the cell the gene product is active
- synapse
- plasma membrane