Camkk2 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity; calcium/calmodulin-dependent protein kinase activity; and calmodulin binding activity. Predicted to be involved in CAMKK-AMPK signaling cascade; positive regulation of protein phosphorylation; and protein autophosphorylation. Predicted to be located in cytosol. Is expressed in central nervous system; dorsal root ganglion; neural retina; testis; and trigeminal nerve. Orthologous to human CAMKK2 (calcium/calmodulin dependent protein kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Camkk2 |
| Official Name | calcium/calmodulin-dependent protein kinase kinase 2, beta [Source:MGI Symbol;Acc:MGI:2444812] |
| Ensembl ID | ENSMUSG00000029471 |
| Bio databases IDs | |
| Aliases | calcium/calmodulin-dependent protein kinase kinase 2, beta |
| Synonyms | 6330570N16Rik, AW061083, calcium/calmodulin-dependent protein kinase kinase 2, calcium/calmodulin-dependent protein kinase kinase 2, beta, calcium/calmodulin-dependent protein kinase kinase 2, β, CAMKK, CAMKKB, CaMKK beta, CaMKK β, mKIAA0787 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Camkk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- autoinhibitory protein domain
- calmodulin binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- calcium ion binding
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- calmodulin regulated protein kinase
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Camkk2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- liver cholangiocarcinoma
- liver cancer
- organismal death
- Huntington disease
- exhaustion
- non-insulin-dependent diabetes mellitus
- cholangiocarcinoma cancer
- obesity
- productive infection by HIV-1
role in cell
- activation in
- apoptosis
- differentiation
- phosphorylation in
- proliferation
- loss
- expression in
- production in
- downregulation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Camkk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- regulation of protein kinase activity
- positive regulation of transcription, DNA-dependent
- positive regulation of protein phosphorylation
- protein autophosphorylation
- calcium-mediated signaling
- protein phosphorylation
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- cytosol
- neuron projection
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- calmodulin binding
- calcium ion binding
- calmodulin-dependent protein kinase activity
- protein serine/threonine kinase activity