Cep63 Gene Summary [Mouse]
This gene encodes a subunit of the centrosome, the main microtubule-organizing center of the cell. The encoded protein associates with another centrosomal protein, CEP152, to regulate mother-centriole-dependent centriole duplication in dividing cells. Disruption of a similar gene in human has been associated with primary microcephaly (MCPH). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | Cep63 |
| Official Name | centrosomal protein 63 [Source:MGI Symbol;Acc:MGI:2158560] |
| Ensembl ID | ENSMUSG00000032534 |
| Bio databases IDs | |
| Aliases | centrosomal protein 63 |
| Synonyms | 4921501M07, AL450317.13gm1, CD20R, centrosomal protein 63, D9Mgc41, D9Mgc48e, ET2, FLJ13386, SCKL6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cep63 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RIM-binding protein of the cytomatrix active zone
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Septation ring formation regulator, EzrA
- Centrosomal protein of 63 kDa
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal bodies
- centrosome
- centriole
- cytosol
- nucleoplasm
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cep63 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- DNA damage checkpoint
- spindle assembly
- centriole replication
- negative regulation of protein K63-linked ubiquitination
- signal transduction in response to DNA damage
- protein stabilization
- negative regulation of innate immune response
Cellular Component
Where in the cell the gene product is active
- centrosome
- centriole
- centriolar satellite
- spindle pole
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- binding, bridging