Gorasp1 Gene Summary [Mouse]
Predicted to enable metal ion binding activity. Involved in Golgi ribbon formation. Acts upstream of or within Golgi organization and protein N-linked glycosylation. Located in Golgi apparatus. Is expressed in cortical layer V and hippocampus CA1. Orthologous to human GORASP1 (golgi reassembly stacking protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gorasp1 |
| Official Name | golgi reassembly stacking protein 1 [Source:MGI Symbol;Acc:MGI:1921748] |
| Ensembl ID | ENSMUSG00000032513 |
| Bio databases IDs | |
| Aliases | golgi reassembly stacking protein 1 |
| Synonyms | 5430411C10Rik, FLJ23443, golgi reassembly stacking protein 1, GOLPH5, GRASP65, P65 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gorasp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- GRASP55/65 PDZ-like domain
- GRASP domain
- canonical PDZ domain
- plk binding domain
- GM130 binding domain
- protein binding
- PDZ domain
- phosphorylation site
- cpPDZ_RseP_YlbL-like
- serine-proline rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric epithelial cancer
- gastric adenocarcinoma
- acute myeloid leukemia
- infection by Dengue virus 2
role in cell
- cell death
- quantity
- formation
- morphology
- fragmentation
- mitosis
- morphogenesis
- stacking
- organization
- M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gorasp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of dendrite morphogenesis
- Golgi organization
- protein transport
- protein N-linked glycosylation
- Golgi ribbon formation
Cellular Component
Where in the cell the gene product is active
- cis-Golgi network
- Golgi membrane
- Golgi apparatus
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding