Fscn1 Gene Summary [Mouse]
Enables actin filament binding activity. Involved in cell migration and positive regulation of filopodium assembly. Acts upstream of or within actin filament bundle assembly. Located in filopodium; growth cone; and lamellipodium. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human FSCN1 (fascin actin-bundling protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fscn1 |
| Official Name | fascin actin-bundling protein 1 [Source:MGI Symbol;Acc:MGI:1352745] |
| Ensembl ID | ENSMUSG00000029581 |
| Bio databases IDs | |
| Aliases | fascin actin-bundling protein 1 |
| Synonyms | FAN1, Fascin, FASCIN1, fascin actin-bundling protein 1, HSN, p55, SNL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fscn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- fascin-like domain, beta-trefoil fold, found in the fascin-like family
- actin binding
- protein binding
- Fascin domain
Pathways
Biological processes and signaling networks where the Fscn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver neoplasia
- neoplasia
- Alzheimer disease
- organismal death
- psoriasis
- metastasis
- breast carcinoma
- colon epithelial cancer
- colon cancer
- colon carcinoma
role in cell
- expression in
- apoptosis
- growth
- phosphorylation in
- invasion by
- proliferation
- differentiation
- number
- ubiquitination in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- filopodial root
- ruffle
- cytoskeleton
- focal adhesions
- podosomes
- actin cytoskeleton
- intercellular junctions
- cytosol
- synaptic vesicles
- growth cone
- actin stress fibers
- extracellular matrix
- cellular protrusions
- microvilli
- filopodia
- dendrites
- lamellipodia
- microspikes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fscn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of lamellipodium assembly
- establishment of apical/basal cell polarity
- cell-cell junction assembly
- establishment or maintenance of cell polarity
- positive regulation of filopodium assembly
- cell motility
- positive regulation of extracellular matrix disassembly
- regulation of actin cytoskeleton organization
- parallel actin filament bundle assembly
- microspike assembly
- cell migration
- positive regulation of podosome assembly
- actin cytoskeleton organization
- actin filament bundle assembly
- regulation of microvillus assembly
Cellular Component
Where in the cell the gene product is active
- podosome
- growth cone
- microspike
- cell-cell junction
- cytoskeleton
- extracellular vesicular exosome
- microvillus
- cytoplasm
- cell cortex
- stress fiber
- actin cytoskeleton
- ruffle
- filopodium
- cytosol
- cell projection membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- RNA binding
- actin binding
- cadherin binding
- protein binding, bridging