Rnf6 Gene Summary [Mouse]
Enables DNA binding activity and ubiquitin protein ligase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within negative regulation of axon extension and positive regulation of DNA-templated transcription. Located in PML body; axon; and cytoplasm. Is expressed in central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma and squamous cell carcinoma. Orthologous to human RNF6 (ring finger protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf6 |
| Official Name | ring finger protein (C3H2C3 type) 6 [Source:MGI Symbol;Acc:MGI:1921382] |
| Ensembl ID | ENSMUSG00000029634 |
| Bio databases IDs | |
| Aliases | ring finger protein (C3H2C3 type) 6 |
| Synonyms | 1200013I08RIK, 5730419H05Rik, LOC102724232, ring finger protein 6, ring finger protein (C3H2C3 type) 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- androgen receptor binding
- Ring finger domain
- protein binding
- RING-like zinc finger
- DNA binding
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- digestive system cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- diabetes mellitus
- gastrointestinal tract cancer
- non-insulin-dependent diabetes mellitus
- esophageal squamous cell cancer
- esophageal carcinoma formation
role in cell
- expression in
- growth
- apoptosis
- migration
- activation in
- proliferation
- K63 polyubiquitination in
- outgrowth
- invasion by
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- plasma membrane projections
- nuclear envelope
- growth cone
- PML nuclear bodies
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- negative regulation of axon extension
- axon extension
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- protein K6-linked ubiquitination
- protein K27-linked ubiquitination
- regulation of androgen receptor signaling pathway
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- PML body
- cytoplasm
- intracellular membrane-bounded organelle
- axon
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ubiquitin-protein ligase activity
- protein binding
- androgen receptor binding
- metal ion binding