Odad3 Gene Summary [Mouse]
Involved in cilium movement; outer dynein arm assembly; and regulation of cilium assembly. Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and seminiferous tubule development. Located in centriole and ciliary basal body. Is active in sperm flagellum. Is expressed in node; testis; and trachea. Used to study Kartagener syndrome and primary ciliary dyskinesia 30. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 30. Orthologous to human ODAD3 (outer dynein arm docking complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Odad3 |
| Official Name | outer dynein arm docking complex subunit 3 [Source:MGI Symbol;Acc:MGI:1924859] |
| Ensembl ID | ENSMUSG00000039632 |
| Bio databases IDs | |
| Aliases | outer dynein arm docking complex subunit 3 |
| Synonyms | b2b1885Clo, C330001K17Rik, CCDC151, CILD30, LOC101060756, ODA10, outer dynein arm docking complex subunit 3, RGD1310048 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Odad3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary ciliary dyskinesia type 30
- Kartagener syndrome
- congenital heart disease
- primary ciliary dyskinesia
- hereditary disorder
regulated by
regulates
- Axonemal Dynein Outer Arm
role in cell
- organization
- assembly
- movement
- morphogenesis
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- basal bodies
- centriole
- axonemes
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Odad3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- epithelial cilium movement involved in determination of left/right asymmetry
- outer dynein arm assembly
- sperm motility
- determination of heart left/right asymmetry
- spermatogenesis
- cilium movement
- brain development
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- ciliary rootlet
- centriole
- cilium basal body
- cilium
- extracellular region
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding