Pcolce Gene Summary [Mouse]
Predicted to enable collagen binding activity; heparin binding activity; and peptidase activator activity. Acts upstream of or within cellular response to leukemia inhibitory factor and proteolysis. Located in extracellular space. Is expressed in several structures, including adrenal gland; branchial arch; embryo endoderm; lower jaw; and umbilical blood vessel. Orthologous to human PCOLCE (procollagen C-endopeptidase enhancer). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pcolce |
| Official Name | procollagen C-endopeptidase enhancer protein [Source:MGI Symbol;Acc:MGI:105099] |
| Ensembl ID | ENSMUSG00000029718 |
| Bio databases IDs | |
| Aliases | procollagen C-endopeptidase enhancer protein |
| Synonyms | ASTT2, P14, PCPE, PCPE-1, procollagen C-endopeptidase enhancer, Procollagen C-Endopeptidase Enhancer 1, procollagen C-endopeptidase enhancer protein, Procollagen c-proteinase enhancer |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcolce often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- CUB
- collagen binding
- protein binding
- protease activator
- heparin binding
- NTR domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
- adenoma formation
- colorectal neoplasia
- breast cancer
- angioimmunoblastic T-cell lymphoma
- organismal death
- colorectal cancer
- hypertrophic scarring
- early missed abortion
role in cell
- morphology
- processing in
- structure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcolce gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- collagen biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- peptidase activator activity
- protein binding
- collagen binding
- heparin binding
- extracellular matrix structural constituent