Sertad1 Gene Summary [Mouse]
Predicted to enable transcription coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus and sarcoplasm. Is expressed in several structures, including 1st branchial arch; early embryo; genitourinary system; heart; and limb. Orthologous to human SERTAD1 (SERTA domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sertad1 |
| Official Name | SERTA domain containing 1 [Source:MGI Symbol;Acc:MGI:1913438] |
| Ensembl ID | ENSMUSG00000008384 |
| Bio databases IDs | |
| Aliases | SERTA domain containing 1 |
| Synonyms | 1110032C13Rik, SEI1, SERTA domain containing 1, TRIP-Br1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sertad1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
- SERTA motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- epileptic seizure
- organismal death
- sarcoidosis
role in cell
- proliferation
- growth
- expression in
- quantity
- colony formation
- formation
- binding in
- mass
- formation in
- sister chromatid exchange in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- sarcoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sertad1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- sarcoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding