Irf5 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and protein kinase binding activity. Involved in cytokine-mediated signaling pathway; defense response to other organism; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; ovary; and urinary system. Human ortholog(s) of this gene implicated in herpes simplex; inflammatory bowel disease 14; multiple sclerosis; rheumatoid arthritis; and systemic lupus erythematosus. Orthologous to human IRF5 (interferon regulatory factor 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irf5 |
| Official Name | interferon regulatory factor 5 [Source:MGI Symbol;Acc:MGI:1350924] |
| Ensembl ID | ENSMUSG00000029771 |
| Bio databases IDs | |
| Aliases | interferon regulatory factor 5 |
| Synonyms | interferon regulatory factor 5, mirf5, SLEB10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Irf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- protein kinase binding
- autoinhibitory protein domain
- DNA binding domain
- IRF
- Irf binding domain
- nuclear localization sequence
- Interferon-regulatory factor 3
- protein binding
- sequence-specific DNA binding
- identical protein binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- Rev activation domain
Pathways
Biological processes and signaling networks where the Irf5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- rheumatoid arthritis
- fibrosis
- susceptibility to systemic lupus erythematosus type 10
- systemic lupus erythematosus
- systemic sclerosis
- inflammatory bowel disease
- hypothyroidism
- liver cancer
- epithelial cancer
role in cell
- binding in
- expression in
- activation in
- differentiation
- replication in
- quantity
- activation
- size
- apoptosis
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Irf5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to peptidoglycan
- response to muramyl dipeptide
- positive regulation of type I interferon production
- positive regulation of transcription from RNA polymerase II promoter
- immune system process
- regulation of transcription from RNA polymerase II promoter
- positive regulation of interferon-alpha production
- positive regulation of cytokine production involved in immune response
- inflammatory response
- positive regulation of interleukin-12 production
- positive regulation of interferon-beta production
- innate immune response
- cytokine-mediated signaling pathway
- positive regulation of apoptotic process
- defense response to virus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity