Gpnmb Gene Summary [Mouse]
Enables heparin binding activity and integrin binding activity. Involved in several processes, including negative regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; and positive regulation of protein phosphorylation. Acts upstream of or within cell adhesion. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including central nervous system; eye; heart ventricle; hemolymphoid system; and mesenchyme derived from neural crest. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 3. Orthologous to human GPNMB (glycoprotein nmb). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Gpnmb |
| Official Name | glycoprotein (transmembrane) nmb [Source:MGI Symbol;Acc:MGI:1934765] |
| Ensembl ID | ENSMUSG00000029816 |
| Bio databases IDs | |
| Aliases | glycoprotein (transmembrane) nmb |
| Synonyms | DC-HIL, glycoprotein nmb, glycoprotein (transmembrane) nmb, Gnmbp, HGFIN, ipd, NMB, Osteoactivin, PLCA3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpnmb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- PKD domain
- RGD motif
- enzyme
- syndecan binding
- protein binding
- PKAT, KLD domain
- integrin binding
- Cadherin repeat-like domain
- receptor agonist activity
- cytosolic tail domain
- heparin binding
- Repeats in polycystic kidney disease 1 (PKD1) and other proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- non-small cell lung carcinoma
- cognitive impairment
- streptozotocin-induced diabetes
- amyloidosis cutis dyschromia
- Alzheimer disease
- chronic kidney disease
- lung metastasis
- organismal death
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- cell viability
- survival
- activation in
- quantity
- migration
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- Golgi Apparatus
- cytoplasmic vesicles
- melanosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpnmb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive chemotaxis
- signal transduction
- negative regulation of cell proliferation
- cell-cell signaling
- regulation of angiogenesis
- cell adhesion
- positive regulation of protein autophosphorylation
- negative regulation of T cell proliferation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- negative regulation of G1/S transition of mitotic cell cycle
- regulation of tissue remodeling
- negative regulation of T cell activation
- negative regulation of cytokine production
- negative regulation of tumor necrosis factor production
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- melanosome membrane
- early endosome membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- syndecan binding
- chemoattractant activity
- receptor agonist activity
- integrin binding
- heparin binding