Tnfrsf11a Gene Summary [Mouse]
Enables tumor necrosis factor receptor activity. Involved in several processes, including circadian temperature homeostasis; positive regulation of fever generation by positive regulation of prostaglandin secretion; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including lymph node development; multinuclear osteoclast differentiation; and positive regulation of bone resorption. Located in cell surface and membrane raft. Is expressed in bladder; hemolymphoid system; hindlimb long bone; and mandible. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in bone development disease and bone remodeling disease (multiple). Orthologous to human TNFRSF11A (TNF receptor superfamily member 11a). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf11a |
| Official Name | tumor necrosis factor receptor superfamily, member 11a, NFKB activator [Source:MGI Symbol;Acc:MGI:1314891] |
| Ensembl ID | ENSMUSG00000026321 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor receptor superfamily, member 11a, NFKB activator |
| Synonyms | CD265, FEO, LOH18CR1, Ly109, mRANK, ODAR, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, RGD1563614, TNF receptor superfamily member 11A, TRANCE-R, tumor necrosis factor receptor superfamily, member 11a, NFKB activator, tumour necrosis factor receptor superfamily, member 11a, NFKB activator |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfrsf11a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- cytokine binding
- TRAF5 binding domain
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- TRAF6 binding domain
- TRAF binding domain
- cytoplasmic domain
- tumor necrosis factor receptor
- IVVY motif
- transmembrane domain
- intracellular domain
- cytosolic tail domain
- transmembrane receptor
- Receptor activator of the NF-KB cysteine-rich repeat domain 2
Pathways
Biological processes and signaling networks where the Tnfrsf11a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- asthma
- osteoporosis
- allergy
- rheumatoid arthritis
- osteopetrosis
- autosomal recessive osteopetrosis
- autosomal recessive osteopetrosis type 7
role in cell
- migration
- growth
- differentiation
- expression in
- proliferation
- production in
- apoptosis
- formation
- cell death
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- cytosol
- plasma membrane extracellular face
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfrsf11a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- circadian temperature homeostasis
- positive regulation of cell proliferation
- lymph node development
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- response to mechanical stimulus
- response to ethanol
- response to insulin stimulus
- positive regulation of osteoclast differentiation
- mammary gland alveolus development
- ossification
- cellular response to zinc ion starvation
- positive regulation of fever generation by positive regulation of prostaglandin secretion
- signal transduction
- cell-cell signaling
- adaptive immune response
- response to organic cyclic compound
- osteoclast differentiation
- tumor necrosis factor-mediated signaling pathway
- monocyte chemotaxis
- multinuclear osteoclast differentiation
- positive regulation of bone resorption
- positive regulation of ERK1 and ERK2 cascade
- response to interleukin-1
- response to lipopolysaccharide
- response to tumor necrosis factor
Cellular Component
Where in the cell the gene product is active
- membrane raft
- external side of plasma membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- metal ion binding
- tumor necrosis factor-activated receptor activity
- signaling receptor activity
- cytokine binding