Ccr1 Gene Summary [Mouse]
Enables C-C chemokine receptor activity. Involved in negative regulation of innate immune response. Acts upstream of or within inflammatory response; leukocyte chemotaxis; and myeloid cell differentiation. Predicted to be located in neuronal cell body and plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including aorta-gonad-mesonephros; extraembryonic component; limb; and liver. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif chemokine receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccr1 |
| Official Name | chemokine (C-C motif) receptor 1 [Source:MGI Symbol;Acc:MGI:104618] |
| Ensembl ID | ENSMUSG00000025804 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) receptor 1 |
| Synonyms | CC Chemokine Receptor 1, CCL3 receptor, C-C motif chemokine receptor 1, CD191, CHEMOKINE CC1 receptor, CKR-1, CMKBR1, HM145, LOC57301, Mip-1 alpha receptor, MIP1aR, Mip-1 α receptor, SCYAR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- extracellular domain
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- C-C chemokine binding
- ligand-binding domain
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ccr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- pancreatic epithelial cancer
- ductal pancreatic cancer
- abdominal cancer
- digestive system cancer
- liver cancer
role in cell
- expression in
- proliferation
- number
- differentiation
- accumulation
- quantity
- formation in
- production in
- migration
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- plasma membrane extracellular face
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of calcium ion transport
- response to wounding
- cell adhesion
- exocytosis
- cell chemotaxis
- negative regulation of bone mineralization
- chemotaxis
- inflammatory response
- immune response
- positive regulation of osteoclast differentiation
- cytokine-mediated signaling pathway
- calcium ion transport
- calcium-mediated signaling
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- positive regulation of monocyte chemotaxis
- cell-cell signaling
- cell surface receptor signaling pathway
- cellular calcium ion homeostasis
- elevation of cytosolic calcium ion concentration
- negative regulation of gene expression
- monocyte chemotaxis
- chemokine-mediated signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- dendritic cell chemotaxis
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- chemokine (C-C motif) ligand 5 binding
- phosphatidylinositol phospholipase C activity
- protein binding
- chemokine (C-C motif) ligand 7 binding
- C-C chemokine receptor activity
- chemokine receptor activity