Zfp638 Gene Summary [Mouse]
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and sensory organ. Orthologous to human ZNF638 (zinc finger protein 638). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp638 |
| Official Name | zinc finger protein 638 [Source:MGI Symbol;Acc:MGI:1203484] |
| Ensembl ID | ENSMUSG00000030016 |
| Bio databases IDs | |
| Aliases | zinc finger protein 638 |
| Synonyms | mNP220, NP220, ZFML, Zfp638, zinc finger protein 638 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp638 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- double-stranded DNA binding
- Zinc-finger double-stranded RNA-binding
- RNA recognition motif
- U1 zinc finger
- protein binding
- Histone H1-like nucleoprotein HC2
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
disease
- major depression
- T-cell non-Hodgkin disease
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- testicular germ cell tumor
- germ cell neoplasia
- headache
- pervasive developmental disorder
- open-angle glaucoma
- schizophrenia
role in cell
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp638 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of RNA splicing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA binding
- double-stranded DNA binding
- mRNA binding