ZNF638 Gene Summary [Human]
The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ZNF638 |
| Official Name | zinc finger protein 638 [Source:HGNC Symbol;Acc:HGNC:17894] |
| Ensembl ID | ENSG00000075292 |
| Bio databases IDs | |
| Aliases | zinc finger protein 638 |
| Synonyms | mNP220, NP220, ZFML, Zfp638, zinc finger protein 638 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF638 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- double-stranded DNA binding
- Zinc-finger double-stranded RNA-binding
- RNA recognition motif
- U1 zinc finger
- protein binding
- Histone H1-like nucleoprotein HC2
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- T-cell non-Hodgkin disease
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- testicular germ cell tumor
- germ cell neoplasia
- headache
- pervasive developmental disorder
- open-angle glaucoma
- schizophrenia
regulates
role in cell
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF638 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of RNA splicing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA binding
- double-stranded DNA binding
- mRNA binding