Isy1 Gene Summary [Mouse]
Predicted to be involved in generation of catalytic spliceosome for second transesterification step and mRNA 3'-splice site recognition. Predicted to be located in nucleus. Predicted to be part of Prp19 complex and spliceosomal complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to several human genes including ISY1 (ISY1 splicing factor homolog). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Isy1 |
| Official Name | ISY1 splicing factor homolog [Source:MGI Symbol;Acc:MGI:1923310] |
| Ensembl ID | ENSMUSG00000030056 |
| Bio databases IDs | |
| Aliases | ISY1 splicing factor homolog |
| Synonyms | 5830446M03Rik, FSAP33, Isy1-rab43, ISY1 splicing factor homolog, KIAA1160, RGD1307688 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Isy1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Isy1-like splicing family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Isy1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of catalytic spliceosome for second transesterification step
- nuclear mRNA 3'-splice site recognition
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- post-spliceosomal complex
- nucleus
- catalytic step 2 spliceosome
- post-mRNA release spliceosomal complex
- U2-type catalytic step 1 spliceosome
- Prp19 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding