Dvl3

Enables protein-macromolecule adaptor activity. Involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway. Acts upstream of or within Wnt signaling pathway, planar cell polarity pathway; cochlea morphogenesis; and outflow tract septum morphogenesis. Located in cytoplasm. Part of Wnt signalosome. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3 and lung cancer. Orthologous to human DVL3 (dishevelled segment polarity protein 3). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dvl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Dvl3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Dvl3 gene, providing context for its role in the cell.