Tmf1 Gene Summary [Mouse]
Predicted to enable nuclear androgen receptor binding activity and transcription coactivator activity. Involved in regulation of proteasomal protein catabolic process. Acts upstream of or within several processes, including Leydig cell differentiation; regulation of gene expression; and spermatid development. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in mandible and maxilla. Orthologous to human TMF1 (TATA element modulatory factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmf1 |
| Official Name | TATA element modulatory factor 1 [Source:MGI Symbol;Acc:MGI:2684999] |
| Ensembl ID | ENSMUSG00000030059 |
| Bio databases IDs | |
| Aliases | TATA element modulatory factor 1 |
| Synonyms | 7030402D04Rik, ARA160, FLJ39046, Gm153, TATA element modulatory factor 1, TMF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- TATA element modulatory factor 1 DNA binding
- chromosome segregation protein SMC, primarily archaeal type
- transcription regulator
- exonuclease SbcC
- transcription co-activator
- Seryl-tRNA synthetase N-terminal domain
- Autophagy protein ATG17-like domain
- androgen receptor binding
- helix-rich Mycoplasma protein
- coiled-coil domain
- protein binding
- TATA element modulatory factor 1 TATA binding
- Tropomyosin
- RIM-binding protein of the cytomatrix active zone
- BC-box
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic juvenile idiopathic arthritis
role in cell
- apoptosis
- differentiation
- motility
- assembly
- development
- differentiation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of proteasomal protein catabolic process
- luteinizing hormone secretion
- spermatid nucleus differentiation
- positive regulation of transcription from RNA polymerase II promoter
- defense response to bacterium
- negative regulation of gene expression
- acrosome assembly
- sperm motility
- positive regulation of testosterone secretion
- androgen receptor signaling pathway
- Leydig cell differentiation
- positive regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- Golgi apparatus
- endoplasmic reticulum
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- androgen receptor binding
- ligand-dependent nuclear receptor transcription coactivator activity