Hmces Gene Summary [Mouse]
Enables single-stranded DNA binding activity. Involved in double-strand break repair via alternative nonhomologous end joining; positive regulation of isotype switching; and somatic hypermutation of immunoglobulin genes. Predicted to be active in replication fork. Is expressed in several structures, including adipose tissue; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human HMCES (5-hydroxymethylcytosine binding, ES cell specific). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmces |
| Official Name | 5-hydroxymethylcytosine (hmC) binding, ES cell specific [Source:MGI Symbol;Acc:MGI:1914053] |
| Ensembl ID | ENSMUSG00000030060 |
| Bio databases IDs | |
| Aliases | 5-hydroxymethylcytosine (hmC) binding, ES cell specific |
| Synonyms | 5-hydroxymethylcytosine binding, ES cell specific, 5-hydroxymethylcytosine (hmC) binding, ES cell specific, 8430410A17Rik, C3orf37, C3orf37 homolog, DC12, Srap1, SRAPD1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hmces often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOS response associated peptidase (SRAP)
- damaged DNA binding
- single-stranded DNA binding
- lyase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hmces gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- positive regulation of isotype switching
- response to DNA damage stimulus
- somatic hypermutation of immunoglobulin genes
Cellular Component
Where in the cell the gene product is active
- replication fork
Molecular Function
What the gene product does at the molecular level
- protein binding
- DNA-(apurinic or apyrimidinic site) lyase activity
- peptidase activity
- single-stranded DNA binding