Hmces Gene Summary [Rat]
Predicted to enable structural molecule activity. Involved in establishment of Golgi localization and organelle transport along microtubule. Located in Golgi membrane. Human ortholog(s) of this gene implicated in immunodeficiency 128. Orthologous to human COPG1 (COPI coat complex subunit gamma 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmces |
| Official Name | 5-hydroxymethylcytosine binding, ES cell specific [Source:RGD Symbol;Acc:1559800] |
| Ensembl ID | ENSRNOG00000010474 |
| Bio databases IDs | |
| Aliases | 5-hydroxymethylcytosine binding, ES cell specific |
| Synonyms | 5-hydroxymethylcytosine binding, ES cell specific, 5-hydroxymethylcytosine (hmC) binding, ES cell specific, 8430410A17Rik, C3orf37, C3orf37 homolog, DC12, Srap1, SRAPD1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hmces often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOS response associated peptidase (SRAP)
- damaged DNA binding
- single-stranded DNA binding
- lyase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hmces gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- positive regulation of isotype switching
- response to DNA damage stimulus
- somatic hypermutation of immunoglobulin genes
Cellular Component
Where in the cell the gene product is active
- replication fork
Molecular Function
What the gene product does at the molecular level
- protein binding
- DNA-(apurinic or apyrimidinic site) lyase activity
- peptidase activity
- single-stranded DNA binding