Il15ra Gene Summary [Mouse]
Predicted to enable interleukin-15 receptor activity and protein kinase binding activity. Acts upstream of or within positive regulation of natural killer cell differentiation. Located in cytoplasmic vesicle. Is expressed in central nervous system; olfactory epithelium; and retina. Orthologous to human IL15RA (interleukin 15 receptor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il15ra |
| Official Name | interleukin 15 receptor, alpha chain [Source:MGI Symbol;Acc:MGI:104644] |
| Ensembl ID | ENSMUSG00000023206 |
| Bio databases IDs | |
| Aliases | interleukin 15 receptor, alpha chain |
| Synonyms | CD215, IL-15R, IL-15Ralpha, IL-15 Receptor Alpha, IL-15 Receptor α, IL-15Rα, interleukin 15 receptor, alpha chain, interleukin 15 receptor subunit alpha, interleukin 15 receptor subunit α, interleukin 15 receptor α, interleukin 15 receptor, α chain, LOC502145 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il15ra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- extracellular domain
- protein kinase binding
- cytoplasmic domain
- interleukin-15 receptor
- transmembrane domain
- linker domain
- Sushi repeat (SCR repeat)
- protein binding
- cytokine receptor
- transmembrane receptor
- SUSHI repeat
Pathways
Biological processes and signaling networks where the Il15ra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- airway hyperresponsiveness
- acute myeloid leukemia
- pancreatic neoplasia
- cancer
- metastasis
- hypoplasia
- hypernociception
- epithelial cancer
- head and neck squamous cell carcinoma
role in cell
- phosphorylation in
- expression in
- activation
- production in
- cell death
- quantity
- apoptosis
- proliferation
- number
- cellular infiltration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membrane-bounded organelle
- cell surface
- Extracellular Space
- intranuclear region
- cellular membrane
- Nucleus
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- nuclear envelope
- early endosomes
- cytoplasmic vesicles
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il15ra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of natural killer cell differentiation
- negative regulation of neuron projection development
- natural killer cell differentiation
- interleukin-15-mediated signaling pathway
- positive regulation of phagocytosis
- response to nutrient levels
- JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasmic vesicle membrane
- nuclear membrane
- endosome
- Golgi membrane
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- interleukin-15 receptor activity
- cytokine receptor activity