Itgax Gene Summary [Mouse]
Predicted to enable integrin binding activity and receptor tyrosine kinase binding activity. Involved in positive regulation of gene expression and positive regulation of myelination. Acts upstream of or within defense response to virus. Located in external side of plasma membrane. Is expressed in heart and hemolymphoid system. Orthologous to human ITGAX (integrin subunit alpha X). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itgax |
| Official Name | integrin alpha X [Source:MGI Symbol;Acc:MGI:96609] |
| Ensembl ID | ENSMUSG00000030789 |
| Bio databases IDs | |
| Aliases | integrin alpha X |
| Synonyms | CD11C, Complement Receptor 4, Cr4, INTEGRIN alpha X, integrin subunit alpha X, integrin subunit α X, INTEGRIN α X, N418, RGD1561123, SLEB6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itgax often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin alpha cytoplasmic region
- signaling receptor activity
- von Willebrand factor (vWF) type A domain
- von Willebrand factor type A domain
- inserted domain
- protein binding
- FG-GAP-like repeat
- Integrin alpha (beta-propellor repeats)
- Integrin alpha
- receptor tyrosine kinase binding
- vWFA
- integrin binding
- FG-GAP repeat
- transmembrane receptor
- lectin domain
Pathways
Biological processes and signaling networks where the Itgax gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Complement System
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HGF Signaling
- Integrin Signaling
- Molecular Mechanisms of Cancer
- PAK Signaling
- Paxillin Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- IgA nephropathy
- obesity
- androgenic alopecia
- acute myeloid leukemia
- organismal death
- systemic lupus erythematosus
- Alzheimer disease
role in cell
- proliferation
- invasion
- migration
- binding
- differentiation
- activation
- accumulation
- phagocytosis
- transmigration
- uptake
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- membrane surface
- cellular membrane
- podosomes
- Nucleus
- secretory granule membrane
- tertiary granule membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itgax gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- positive regulation of cell proliferation
- cell adhesion
- positive regulation of angiogenesis
- organ morphogenesis
- cell adhesion mediated by integrin
- integrin-mediated signaling pathway
- positive regulation of gene expression
- defense response to virus
- heterotypic cell-cell adhesion
- positive regulation of myelination
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- membrane
- external side of plasma membrane
- integrin complex
- tertiary granule membrane
- plasma membrane
- cell surface
- alphaX-beta2 integrin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- signaling receptor activity
- integrin binding
- receptor tyrosine kinase binding