DPF1 Gene Summary [Human]
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated; nervous system development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of nBAF complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DPF1 |
| Official Name | double PHD fingers 1 [Source:HGNC Symbol;Acc:HGNC:20225] |
| Ensembl ID | ENSG00000011332 |
| Bio databases IDs | |
| Aliases | double PHD fingers 1 |
| Synonyms | BAF45b, double PHD fingers 1, NEUD4, neuro-d4, SMARCG1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DPF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- double-stranded DNA binding
- PHD finger superfamily
- protein binding
- DPF1-3, N-terminal
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the DPF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DPF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- chromatin remodeling
- apoptotic process
- nervous system development
- positive regulation of cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of nucleotide-excision repair
- regulation of G0 to G1 transition
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nBAF complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- metal ion binding