Nup153 Gene Summary [Mouse]
Predicted to enable several functions, including molecular condensate scaffold activity; nuclear localization sequence binding activity; and small GTPase binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including amyloid fibril formation; negative regulation of RNA export from nucleus; and nucleocytoplasmic transport. Predicted to be located in annulate lamellae; cytosol; and nucleus. Predicted to be part of nuclear pore nuclear basket. Is expressed in several structures, including central nervous system; lung; and retina. Orthologous to human NUP153 (nucleoporin 153). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup153 |
| Official Name | nucleoporin 153 [Source:MGI Symbol;Acc:MGI:2385621] |
| Ensembl ID | ENSMUSG00000021374 |
| Bio databases IDs | |
| Aliases | nucleoporin 153 |
| Synonyms | B130015D15Rik, HNUP153, N153, nucleoporin 153, NUCZINK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nup153 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- enzyme binding
- chromatin binding
- protein binding
- nuclear localization sequence binding
- identical protein binding
- Nucleoporin Nup153-like
- Retro-transposon transporting motif
- FG repeat
- Zn-finger in Ran binding protein and others
- zinc ion binding
- double-stranded DNA binding
- structural constituent of nuclear pore
- zinc finger domain
Pathways
Biological processes and signaling networks where the Nup153 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cholelithiasis
- gallstone
- ovarian carcinoma
- epithelial ovarian cancer
- acute myeloid leukemia
- infection by HIV-1
role in cell
- formation
- assembly
- transcription in
- replication in
- misalignment in
- misalignment
- breakdown
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- endomembrane system
- Cytoplasm
- cellular membrane
- cytosol
- nuclear foci
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- nucleoli
- nuclear rim
- nuclear envelope
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nup153 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- nucleocytoplasmic transport
- RNA export from nucleus
- protein import into nucleus
- negative regulation of RNA export from nucleus
- nuclear pore complex assembly
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear inclusion body
- nuclear membrane
- membrane
- cytosol
- nuclear periphery
- nucleolus
- host cell
- nucleoplasm
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding
- metal ion binding
- protein anchor
- structural constituent of nuclear pore
- nuclear localization sequence binding