Fchsd2 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in membrane organization and positive regulation of actin filament polymerization. Located in stereocilium shaft. Is expressed in cerebral cortex ventricular layer; cortical plate; tail dorsal root ganglion; and trigeminal ganglion. Orthologous to human FCHSD2 (FCH and double SH3 domains 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fchsd2 |
| Official Name | FCH and double SH3 domains 2 [Source:MGI Symbol;Acc:MGI:2448475] |
| Ensembl ID | ENSMUSG00000030691 |
| Bio databases IDs | |
| Aliases | FCH and double SH3 domains 2 |
| Synonyms | BC034086, FCH and double SH3 domains 2, KIAA0769, mKIAA0769, NWK, NWK1, R74866, SH3MD3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fchsd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- phosphatidylinositol-3,4,5-triphosphate binding
- Fes/CIP4, and EFC/F-BAR homology domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometrial carcinoma
- epithelial endometrial cancer
- Crohn disease
- colorectal carcinoma
- colorectal carcinomagenesis
- survival
- endometriosis
- insomnia
- psoriasis
- systemic lupus erythematosus
role in cell
- expression in
- apoptosis
- proliferation
- migration
- formation
- Clathrin mediated endocytosis by
- phosphorylation in
- accumulation in
- formation in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- clathrin-coated pits
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fchsd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
- clathrin-mediated endocytosis
- membrane organization
- neuromuscular synaptic transmission
- positive regulation of actin filament polymerization
- protein transport
- positive regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- anchoring junction
- coated pit
- neuromuscular junction
- recycling endosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- protein binding
- phosphatidylinositol-3,4-bisphosphate binding