Art1 Gene Summary [Mouse]
Enables NAD+ poly-ADP-ribosyltransferase activity. Located in cell surface and membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human ART1 (ADP-ribosyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Art1 |
| Official Name | ADP-ribosyltransferase 1 [Source:MGI Symbol;Acc:MGI:107511] |
| Ensembl ID | ENSMUSG00000030996 |
| Bio databases IDs | |
| Aliases | ADP-ribosyltransferase 1 |
| Synonyms | ADP-ribosyltransferase 1, ADPRT, ART2, ARTC1, CD296, RT6, Yac-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Art1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- VIP2
- pentosyltransferase
- NAD ADP-ribosyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- NAD+
- YY1
regulated by
- tetradecanoylphorbol acetate
- diethyl pyrocarbonate
- NGEF
- 3-iodobenzylguanidine
- PLC
disease
- colorectal cancer
phenotypes
- abnormal behavior
- abnormal skin morphology
- decreased exploration in new environment
- enlarged lymph nodes
- hyperactivity
- increased anxiety-related response
- increased thigmotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- sarcoplasmic reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Art1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- NAD+ ADP-ribosyltransferase activity