Sharpin Gene Summary [Mouse]
Enables protein-macromolecule adaptor activity. Involved in negative regulation of inflammatory response; positive regulation of canonical NF-kappaB signal transduction; and regulation of tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including canonical NF-kappaB signal transduction; keratinization; and negative regulation of canonical NF-kappaB signal transduction. Part of LUBAC complex. Is expressed in several structures, including cochlear ganglion; genitourinary system; heart; inner ear epithelium; and lung. Used to study atopic dermatitis. Orthologous to human SHARPIN (SHANK associated RH domain interactor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Sharpin |
| Official Name | SHANK-associated RH domain interacting protein [Source:MGI Symbol;Acc:MGI:1913331] |
| Ensembl ID | ENSMUSG00000022552 |
| Bio databases IDs | |
| Aliases | SHANK-associated RH domain interacting protein |
| Synonyms | 0610041B22RIK, AIFID, Conneck1, cpdm, DKFZP434N1923, RBCKL1, SHANK-associated RH domain interacting protein, SHANK-associated RH domain interactor, SIPL1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sharpin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NZF domain
- Zn-finger in Ran binding protein and others
- binding protein
- Sharpin PH domain
- Ubl1_cv_Nsp3_N-like
- protein binding activity, bridging
- protein binding
- zinc finger domain
- Pleckstrin homology-like domain
- identical protein binding
Pathways
Biological processes and signaling networks where the Sharpin gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- neoplasia
- osteopenia
- Alzheimer disease
- mantle cell lymphoma
- dermatitis
- chronic proliferative dermatitis
- asthma
- delayed hypersensitive reaction
- respiratory disorder
phenotypes
- abnormal angiogenesis
- abnormal coat appearance
- abnormal dermal layer morphology
- abnormal epidermal layer morphology
- abnormal epidermis stratum basale morphology
- abnormal epidermis stratum corneum morphology
- abnormal epidermis stratum granulosum morphology
- abnormal esophageal epithelium morphology
- abnormal hair follicle morphology
- abnormal hair shaft morphology
- abnormal humoral immune response
- abnormal immune system organ morphology
- abnormal liver morphology
- abnormal lung interstitium morphology
- abnormal lymph node morphology
- abnormal mesenteric lymph node morphology
- abnormal peripheral lymph node morphology
- abnormal spleen B cell follicle morphology
- abnormal spleen morphology
- abnormal spleen white pulp morphology
- abnormal stomach epithelium morphology
- abnormal synovial joint capsule morphology
- abnormal tongue squamous epithelium morphology
- absent Peyer's patches
- absent spleen germinal center
- absent spleen marginal zone
- acanthosis
- alopecia
- decreased B cell number
- decreased CD4-positive alpha beta T cell number
- decreased IgA level
- decreased IgE level
- decreased IgG level
- decreased T cell number
- decreased immunoglobulin level
- dermatitis
- enlarged spleen
- epidermal hyperplasia
- esophageal inflammation
- extramedullary hematopoiesis
- female infertility
- folliculitis
- hyperkeratosis
- increased IgM level
- increased bone marrow cell number
- increased eosinophil cell number
- increased keratinocyte apoptosis
- increased keratinocyte proliferation
- increased mast cell number
- increased pruritus
- joint inflammation
- large lymphoid organs
- lung inflammation
- lymph node inflammation
- mixed cellular infiltration to dermis
- parakeratosis
- postnatal growth retardation
- premature hair loss
- reddish skin
- reduced male fertility
- scaly skin
- skin edema
- skin inflammation
- skin lesions
- stomach inflammation
- thick epidermis
- thick epidermis stratum basale
- thick eyelids
- weight loss
role in cell
- binding in
- phosphorylation in
- expression in
- activation in
- differentiation
- degradation in
- number
- quantity
- production in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell periphery
- cytosol
- membrane ruffles
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sharpin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- apoptotic nuclear change
- negative regulation of inflammatory response
- protein linear polyubiquitination
- regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- keratinization
- regulation of CD40 signaling pathway
- defense response to bacterium
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytosol
- synapse
- LUBAC complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- protein binding
- ubiquitin binding
- metal ion binding
- polyubiquitin binding
- protein binding, bridging