Mcf2 Gene Summary [Mouse]
Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within cellular response to leukemia inhibitory factor and dendrite development. Predicted to be active in cytoplasm. Is expressed in femur; fibula; and tibia. Orthologous to human MCF2 (MCF.2 cell line derived transforming sequence). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcf2 |
| Official Name | mcf.2 transforming sequence [Source:MGI Symbol;Acc:MGI:96932] |
| Ensembl ID | ENSMUSG00000031139 |
| Bio databases IDs | |
| Aliases | mcf.2 transforming sequence |
| Synonyms | ARHGEF21, B230117G22Rik, DBL, LOC102555789, MCF.2 cell line derived transforming sequence, mcf.2 transforming sequence, RGD1566098 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in homologues of a S
- SPEC
- Spectrin repeats
- RhoGEF
- spectrin homology domain
- Divergent CRAL/TRIO domain
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Dbl homology domain
- RhoGEF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic sclerosis
role in cell
- growth
- migration
- cell death
- activation in
- development
- survival
- formation
- invasion
- morphology
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cytoskeleton
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of axonogenesis
- regulation of small GTPase mediated signal transduction
- intracellular signal transduction
- dendrite development
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- membrane
- cytosol
- extrinsic to membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity