Pik3c2b Gene Summary [Mouse]
Enables lipid kinase activity. Acts upstream of or within several processes, including autophagosome organization; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and phosphatidylinositol-3-phosphate biosynthetic process. Located in endocytic vesicle. Is expressed in eye; limb; liver; nervous system; and skeleton. Orthologous to human PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pik3c2b |
| Official Name | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [Source:MGI Symbol;Acc:MGI:2685045] |
| Ensembl ID | ENSMUSG00000026447 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta |
| Synonyms | C2-PI3K, C330011J12, C330011J12Rik, Gm199, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 β, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 β, PI3K-C2beta, Pi3k β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pik3c2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid kinase
- Phosphatidylinositol 3- and 4-kinase
- protein binding
- PI3-kinase family, ras-binding domain
- proline rich domain
- PI3Ka
- kinase
- phosphatidylinositol 3-kinase
- phosphatidylinositol-4-phosphate 3-kinase
- Phosphoinositide 3-kinase, catalytic domain
- Protein Kinases, catalytic domain
- The Phox Homology domain, a phosphoinositide binding module
- Protein kinase C conserved region 2 (CalB)
- PX domain
- C2 domain
Pathways
Biological processes and signaling networks where the Pik3c2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- ErbB Signaling
- ErbB4 Signaling
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Mouse Embryonic Stem Cell Pluripotency
- MSP-RON Signaling Pathway
- Neurotrophin/TRK Signaling
- NGF Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th1 Pathway
- Th2 Pathway
- Thyroid Cancer Signaling
- UVA-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- acute myeloid leukemia
- brain edema
- allergic rhinitis
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- vascular leak syndrome
- cerebral infarction
- nasopharyngeal carcinoma
role in cell
- degradation in
- activation in
- expression in
- migration
- growth
- accumulation in
- assembly
- number
- morphogenesis
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- cytosol
- microsome
- nucleoplasm
- nuclear envelope
- endocytotic vesicle
- clathrin-coated pits
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pik3c2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein kinase B signaling cascade
- phosphatidylinositol-mediated signaling
- phosphatidylinositol-3-phosphate biosynthetic process
- cellular response to starvation
- cell migration
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
- endocytic vesicle
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- endoplasmic reticulum
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- phosphatidylinositol binding
- 1-phosphatidylinositol-4-phosphate 3-kinase activity
- 1-phosphatidylinositol-3-kinase activity