Decr1 Gene Summary [Mouse]
Predicted to enable 2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding activity; and identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Located in mitochondrion. Is expressed in axial skeleton and heart. Orthologous to human DECR1 (2,4-dienoyl-CoA reductase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Decr1 |
| Official Name | 2,4-dienoyl CoA reductase 1, mitochondrial [Source:MGI Symbol;Acc:MGI:1914710] |
| Ensembl ID | ENSMUSG00000028223 |
| Bio databases IDs | |
| Aliases | 2,4-dienoyl CoA reductase 1, mitochondrial |
| Synonyms | 1200012F07Rik, 2,4-Dienoyl coa reductase, 2,4-dienoyl-CoA reductase 1, 2,4-dienoyl CoA reductase 1, mitochondrial, 2,4 Dienoyl Reductase, DECR, NADPH, SDR18C1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Decr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2-deoxy-D-gluconate 3-dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- NADPH binding
- 2,4-dienoyl-CoA reductase (NADPH2)
- pteridine reductase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- neoplasia
- early onset hypertension
- non-insulin-dependent diabetes mellitus
- insomnia
- mammary neoplasm
- microvesicular hepatic steatosis
- tremor
role in cell
- activation in
- apoptosis
- proliferation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial membrane
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Decr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- 2,4-dienoyl-CoA reductase (NADPH) activity
- NADPH binding