Slc38a5 Gene Summary [Mouse]
Enables L-glutamine, sodium:proton antiporter activity. Involved in L-glutamine import across plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; foregut-midgut junction; liver lobe; metanephros; and pericardium. Orthologous to human SLC38A5 (solute carrier family 38 member 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc38a5 |
| Official Name | solute carrier family 38, member 5 [Source:MGI Symbol;Acc:MGI:2148066] |
| Ensembl ID | ENSMUSG00000031170 |
| Bio databases IDs | |
| Aliases | solute carrier family 38, member 5 |
| Synonyms | AF276870, C81234, E330031E14, JM24, PP7194, SN2, SNAT5, solute carrier family 38 member 5, solute carrier family 38, member 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc38a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic acid transporter
- glycine transporter
- asparagine transporter
- glutamine transporter
- histidine transporter
- cation transporter
- sodium:hydrogen antiporter
- neutral amino acid transporter
- organic cation transporter
- antiporter
- Solute carrier families 5 and 6-like; solute binding domain
- serine transporter
- amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- motor dysfunction
- structural anomaly
regulates
- glutamine
- L-glutamine
- L-histidine
- glycine
- amino acids
- neutral amino acid
- L-serine
- KDR
- asparagine
- L-alanine
role in cell
- proliferation
- migration
- damage
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc38a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamine transport
- serine transport
- asparagine transport
- glycine transport
- neutral amino acid transport
- sodium ion transmembrane transport
- L-serine transport
- amino acid transport
- amino acid export
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- L-histidine transmembrane transporter activity
- alanine transmembrane transporter activity
- glycine transmembrane transporter activity
- L-glutamine transmembrane transporter activity
- L-serine transmembrane transporter activity
- amino acid transmembrane transporter activity
- L-asparagine transmembrane transporter activity