Kcnk1 Gene Summary [Mouse]
Enables identical protein binding activity; protein heterodimerization activity; and voltage-gated monoatomic ion channel activity. Involved in chloride transmembrane transport; glutamate secretion; and potassium ion transmembrane transport. Located in endosome and plasma membrane. Part of inward rectifier potassium channel complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human KCNK1 (potassium two pore domain channel subfamily K member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnk1 |
| Official Name | potassium channel, subfamily K, member 1 [Source:MGI Symbol;Acc:MGI:109322] |
| Ensembl ID | ENSMUSG00000033998 |
| Bio databases IDs | |
| Aliases | potassium channel, subfamily K, member 1 |
| Synonyms | DPK, HOHO, HOHO1, K2P1, K2p1.1, KCNO1, Knk1, potassium channel, subfamily K, member 1, potassium two pore domain channel subfamily K member 1, Twik, TWIK-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- inward rectifier potassium channel
- sodium channel
- Sumoylation motif
- channel/pore class transporter
- protein binding
- identical protein binding
- voltage-gated ion channel
- ion channel
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- dementia
- glioma
- glioma formation
- hypophosphatemia
- epileptic seizure
- phosphaturia
regulates
- L-glutamic acid
- chloride
- K+
- phosphate
- Na+
role in cell
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- endosomes
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- regulation of resting membrane potential
- sodium ion transmembrane transport
- response to nicotine
- stabilization of membrane potential
Cellular Component
Where in the cell the gene product is active
- dendrite
- potassium channel complex
- brush border membrane
- voltage-gated potassium channel complex
- intracellular membrane-bounded organelle
- membrane
- recycling endosome
- synaptic membrane
- perikaryon
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- identical protein binding
- protein binding
- sodium channel activity
- inward rectifier potassium channel activity
- outward rectifier potassium channel activity
- potassium channel activity
- potassium ion leak channel activity