Cox7b Gene Summary [Mouse]
Predicted to be involved in central nervous system development. Located in mitochondrion. Part of respiratory chain complex IV. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 2. Orthologous to human COX7B (cytochrome c oxidase subunit 7B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox7b |
| Official Name | cytochrome c oxidase subunit 7B [Source:MGI Symbol;Acc:MGI:1913392] |
| Ensembl ID | ENSMUSG00000031231 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase subunit 7B |
| Synonyms | 1110004F07Rik, APLCC, cytochrome c oxidase subunit 7B, LSDMCA2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cox7b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- enzyme
- protein binding
- Cyt_c_Oxidase_VIIb
Pathways
Biological processes and signaling networks where the Cox7b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- reticulolinear aplasia cutis congenita with microcephaly, facial dysmorphism, and other congenital anomalies
- metabolic syndrome X
- Turner syndrome
- Huntington disease
- chronic obstructive pulmonary disease
- insulin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cox7b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- mitochondrial electron transport, cytochrome c to oxygen
- cellular respiration
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- respiratory chain complex IV
- mitochondrion
- mitochondrial respiratory chain complex IV
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytochrome-c oxidase activity