Igbp1 Gene Summary [Mouse]
Enables mitogen-activated protein kinase kinase binding activity and protein domain specific binding activity. Involved in positive regulation of dephosphorylation and positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of apoptotic signaling pathway. Located in cytoplasm and microtubule. Is expressed in central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome. Orthologous to several human genes including IGBP1 (immunoglobulin binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igbp1 |
| Official Name | immunoglobulin (CD79A) binding protein 1 [Source:MGI Symbol;Acc:MGI:1346500] |
| Ensembl ID | ENSMUSG00000031221 |
| Bio databases IDs | |
| Aliases | immunoglobulin (CD79A) binding protein 1 |
| Synonyms | AI662457, AIpha 4, Alpha 4, C81413, IBP1, IG alpha BP1, IG α BP1, immunoglobulin binding protein 1, immunoglobulin (CD79A) binding protein 1, MRXS28, p52, Pc52, Protein Phosphatase 2A AIpha4, Protein Phosphatase 2A Alpha4, Tap42, α-4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TAP42-like family
- binding protein
- protein kinase binding
- protein phosphatase binding
- phosphatase
- protein phosphatase regulator
- enzyme binding
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- villous atrophy of intestine
- crypt hyperplasia
- agenesis of corpus callosum with mental retardation, ocular coloboma, and micrognathia
role in cell
- proliferation
- expression in
- migration
- activation in
- degradation in
- ubiquitination in
- phosphorylation in
- signaling in
- cell spreading
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- microtubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- signal transduction
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- response to interleukin-1
- negative regulation of stress-activated MAPK cascade
- B cell activation
- regulation of microtubule-based movement
- regulation of dephosphorylation
- response to tumor necrosis factor
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase 2A binding
- protein phosphatase regulator activity